DMPK

Across TCGA patient cohorts, DMPK mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMPK-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4E. Each is linked with DMPK in more than 1 cancer types. Because this analysis shows association rather than direction, both DMPK-to-partner and partner-to-DMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DMPK-low versus DMPK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMPK→partner) and Y-score (partner→DMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.317	+2.000	.009	.029	3	2
UCEC	EGFR_pY1068 →	-0.246	-2.321	.004	.005	3	2
UCEC	eIF4E →	+0.179	+1.807	.012	.004	3	2
UCEC	ERK2 →	+0.186	+3.459	.004	.005	3	2
UCEC	ATM →	-0.418	-2.446	.006	.018	3	2
UCEC	Bak →	+0.196	+1.415	.021	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by DMPK expression — UCEC

Explore this box plot interactively →