DMPK

Across TCGA cell cohorts, DMPK mutation is significantly associated with the mutation status of many other genes, with 2,714 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMPK-associated genes across cancer lineages are KCNH4, USP20, and PLEKHG4B. Each is linked with DMPK in more than 3 cancer types. Because this analysis shows association rather than direction, both DMPK-to-partner and partner-to-DMPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNH4 grouped by DMPK-low versus DMPK-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMPK→partner) and Y-score (partner→DMPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KCNH4 →	+5.044	+5.614	.003	.003	1	4
CNS	USP20 →	+4.044	+5.000	.008	.008	1	4
CNS	PLEKHG4B →	+4.044	+5.000	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	METTL16 →	+5.392	+5.392	.004	.004	1	4
PANCREAS	BICRA →	+3.321	+3.614	.006	.006	1	3
PANCREAS	UBR4 →	+4.906	+4.257	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,714 associations by consensus.

KCNH4 by DMPK expression — CNS

Explore this box plot interactively →