DMKN

Across TCGA patient cohorts, DMKN protein abundance is significantly associated with the RNA expression of many other genes, with 9,172 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DMKN-associated genes across cancer lineages are GJB6, RHCG, and CAPN13. Each is linked with DMKN in more than 2 cancer types. Because this analysis shows association rather than direction, both DMKN-to-partner and partner-to-DMKN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DMKN versus GJB6 in BRCA, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMKN→partner) and Y-score (partner→DMKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GJB6 →	+2.691	+1.765	.001	.002	3	3
HNSC	RHCG →	+2.552	+1.156	<.001	<.001	3	3
BRCA	CAPN13 →	-2.884	-1.489	.003	.003	3	3
HNSC	KRTDAP →	+3.232	+1.465	<.001	<.001	3	3
BRCA	ICA1 →	-1.230	-1.397	<.001	.003	3	3
OV	CFAP91 →	-1.147	-1.160	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,172 associations by consensus.

DMKN vs GJB6 — BRCA

Explore this scatter interactively →