DMKN

Across TCGA patient cohorts, DMKN mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMKN-associated genes across cancer lineages are INPP4B, 14-3-3_beta, and EGFR_pY1068. Each is linked with DMKN in more than 1 cancer types. Because this analysis shows association rather than direction, both DMKN-to-partner and partner-to-DMKN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by DMKN-low versus DMKN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMKN→partner) and Y-score (partner→DMKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.340	-3.584	.007	.002	3	2
UCEC	14-3-3_beta →	-0.094	-1.847	.016	.049	3	1
UCEC	EGFR_pY1068 →	-0.222	-1.584	.024	.036	3	1
UCEC	eIF4E →	+0.227	+3.584	.006	.002	3	1
UCEC	JNK2 →	+0.221	+2.331	.004	.019	3	1
UCEC	MEK1 →	+0.434	+2.502	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

INPP4B by DMKN expression — UCEC

Explore this box plot interactively →