DMKN

Across TCGA cell cohorts, DMKN RNA expression is significantly associated with the go_rna of many other GO terms, with 3,626 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DMKN-associated GO terms across cancer lineages are Bundle of His cell to Purkinje myocyte communication, Negative regulation of actin filament bundle assembly, and Positive regulation of protein import into nucleus. Each is linked with DMKN in more than 8 cancer types. Because this analysis shows association rather than direction, both DMKN-to-partner and partner-to-DMKN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bundle of His cell to Purkinje myocyte communication grouped by DMKN-low versus DMKN-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DMKN→partner) and Y-score (partner→DMKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Bundle of His cell to Purkinje myocyte communication →	+0.986	+3.122	<.001	.002	3	9
STOMACH	Negative regulation of actin filament bundle assembly →	+0.107	+2.859	.003	.001	3	9
BREAST	Positive regulation of protein import into nucleus →	+0.111	+2.829	<.001	<.001	3	9
STOMACH	Negative regulation of stress fiber assembly →	+0.122	+3.861	.003	<.001	3	9
BONE	Negative regulation of apoptotic signaling pathway →	+0.063	+2.008	<.001	<.001	3	9
KIDNEY	Cell-substrate junction assembly →	+0.144	+2.996	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,626 associations by consensus.

Bundle of His cell to Purkinje myocyte communication by DMKN expression — SOFT_TISSUE

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