DMKN

Across TCGA cell cohorts, DMKN mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMKN-associated genes across cancer lineages are GC, WFDC12, and DEFB4A. Each is linked with DMKN in more than 1 cancer types. Because this analysis shows association rather than direction, both DMKN-to-partner and partner-to-DMKN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GC grouped by DMKN-low versus DMKN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMKN→partner) and Y-score (partner→DMKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GC →	+0.156	+4.276	<.001	.007	3	1
BLOOD_Leukemia	WFDC12 →	+0.249	+4.874	<.001	.002	3	1
BLOOD_Leukemia	DEFB4A →	+0.123	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	DAOA →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTDAP →	+0.114	+4.276	<.001	.007	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

GC by DMKN expression — BLOOD_Leukemia

Explore this box plot interactively →