DMGDH

Across TCGA pan-cancer cohorts, DMGDH mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DMGDH data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DMGDH mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DMGDH expression acts as an unfavorable survival marker, although some lineages such as GBM and CCRCC show a favorable association.

GBM, LUAD, and CCRCC are the cancer types where DMGDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.861	0.282	.006	9	view →
LUAD	DFS	Median	All	0.458	0.932	.002	8	view →
CCRCC	DFS	Quartile	All	0.978	0.418	.003	5	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DMGDH–GBM (DFS)

Open the GBM breakdown →