DMGDH

Across TCGA patient cohorts, DMGDH protein abundance is significantly associated with the RNA expression of many other genes, with 1,601 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DMGDH-associated genes across cancer lineages are DYNC1I1, KCTD9P2, and SCN7A. Each is linked with DMGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both DMGDH-to-partner and partner-to-DMGDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DMGDH versus DYNC1I1 in LUAD, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMGDH→partner) and Y-score (partner→DMGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DYNC1I1 →	+0.913	+1.012	<.001	<.001	3	2
BRCA	KCTD9P2 →	+0.880	+0.975	.006	.005	3	2
GBM	SCN7A →	+2.815	+0.738	.008	<.001	3	2
GBM	CALCRL →	+1.683	+0.828	<.001	<.001	3	2
GBM	IFT20 →	-0.580	-0.801	.004	<.001	3	2
GBM	FAM72B →	-0.898	-0.816	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,601 associations by consensus.

DMGDH vs DYNC1I1 — LUAD

Explore this scatter interactively →