DMGDH

Across TCGA patient cohorts, DMGDH mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMGDH-associated genes across cancer lineages are INPP4B, NF-kB-p65_pS536, and 14-3-3_zeta. Each is linked with DMGDH in more than 2 cancer types. Because this analysis shows association rather than direction, both DMGDH-to-partner and partner-to-DMGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by DMGDH-low versus DMGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMGDH→partner) and Y-score (partner→DMGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.249	-2.584	.032	.010	3	3
SKCM	NF-kB-p65_pS536 →	-0.348	-2.415	.025	.003	3	2
SKCM	14-3-3_zeta →	+0.251	+2.321	.002	.033	3	2
UCEC	eEF2 →	+0.369	+1.925	.004	.005	3	2
UCEC	Gab2 →	+0.317	+1.584	.013	.019	3	2
UCEC	GAPDH →	+0.441	+1.584	.022	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

INPP4B by DMGDH expression — UCEC

Explore this box plot interactively →