DMGDH

Across TCGA cell cohorts, DMGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,464 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DMGDH-associated GO terms across cancer lineages are Amino-acid betaine catabolic process, Response to endoplasmic reticulum stress, and Target-directed miRNA degradation. Each is linked with DMGDH in more than 18 cancer types. Because this analysis shows association rather than direction, both DMGDH-to-partner and partner-to-DMGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Amino-acid betaine catabolic process grouped by DMGDH-low versus DMGDH-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DMGDH→partner) and Y-score (partner→DMGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Amino-acid betaine catabolic process →	+1.147	+2.637	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Response to endoplasmic reticulum stress →	+0.047	+0.549	<.001	<.001	3	14
BLOOD_Myeloma	Target-directed miRNA degradation →	+0.097	+1.114	.006	.004	3	13
SOFT_TISSUE	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.113	-0.837	<.001	.001	3	12
LIVER	Establishment of protein localization to endoplasmic reticulum →	+0.109	+1.847	<.001	<.001	3	12
BLOOD_Lymphoma	Protein exit from endoplasmic reticulum →	+0.085	+0.934	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,464 associations by consensus.

Amino-acid betaine catabolic process by DMGDH expression — KIDNEY

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