DMGDH

Across TCGA cell cohorts, DMGDH mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DMGDH-associated genes across cancer lineages are TEX13A, TINAG, and GPR152. Each is linked with DMGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both DMGDH-to-partner and partner-to-DMGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX13A grouped by DMGDH-low versus DMGDH-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMGDH→partner) and Y-score (partner→DMGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TEX13A →	+0.010	+3.604	.001	.004	3	2
SKIN	TINAG →	+0.308	+3.678	<.001	.009	3	1
SKIN	GPR152 →	+0.055	+4.347	<.001	.001	3	1
SKIN	C4orf50 →	+0.022	+3.684	<.001	.006	3	1
LUNG_NSCLC_LUAD	STATH →	+0.183	+3.362	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR1A2 →	+0.011	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

TEX13A by DMGDH expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →