DMC1

Across TCGA pan-cancer cohorts, DMC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DMC1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DMC1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DMC1 expression acts as an unfavorable survival marker.

BLCA, LGG, and UCEC are the cancer types where DMC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Median	All	0.158	0.618	<.001	36	view →
LGG	OS	Median	All	0.192	0.799	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	III,IV	0.121	0.654	.004	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DMC1–BLCA (DFS)

Open the BLCA breakdown →