Across TCGA patient cohorts, DMBT1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMBT1-associated genes across cancer lineages are Cyclin-B1, PKC-a, and Caspase-7-cleavedD198. Each is linked with DMBT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DMBT1-to-partner and partner-to-DMBT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMBT1→partner) and Y-score (partner→DMBT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Cyclin-B1 →	+0.659	+2.700	.001	.006	3	5
COAD	PKC-a →	-0.211	-1.874	.038	.049	3	5
COAD	Caspase-7-cleavedD198 →	+1.214	+3.338	<.001	.004	3	5
LUAD	Chk1 →	+0.197	+2.000	.042	.031	3	4
COAD	FASN →	+0.494	+2.423	<.001	.001	3	4
COAD	4E-BP1 →	+0.218	+2.423	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

DMBT1 survival (RNA) · tumor vs normal (RNA) · all DMBT1 data types