DMAC2L

Across TCGA patient cohorts, DMAC2L mutation is significantly associated with the RNA expression of many other genes, with 1,260 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMAC2L-associated genes across cancer lineages are DAOA, AKR1B1P3, and RNU6-1077P. Each is linked with DMAC2L in more than 1 cancer types. Because this analysis shows association rather than direction, both DMAC2L-to-partner and partner-to-DMAC2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAOA grouped by DMAC2L-low versus DMAC2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMAC2L→partner) and Y-score (partner→DMAC2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DAOA →	+0.069	+2.067	.003	.005	3	2
UCEC	AKR1B1P3 →	+0.292	+2.949	<.001	<.001	3	2
UCEC	RNU6-1077P →	+0.486	+2.089	<.001	.005	3	2
BLCA	HMGB3P21 →	+0.118	+3.809	.009	.009	3	2
UCEC	GCATP1 →	+0.406	+2.949	<.001	<.001	3	1
UCEC	DCP1A →	+0.617	+2.906	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,260 associations by consensus.

DAOA by DMAC2L expression — UCEC

Explore this box plot interactively →