DMAC2

Across TCGA pan-cancer cohorts, DMAC2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DMAC2 data layer compared with 20 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DMAC2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DMAC2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where DMAC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	II,III,IV	0.450	1.000	.015	14	view →
HNSC	DFS	Quartile	All	1.000	0.905	.013	13	view →
LSCC	OS	Median	All	0.939	0.828	.009	12	view →
CCRCC	DFS	Quartile	II,III,IV	0.272	0.816	.002	9	view →
LUAD	OS	Median	All	0.491	0.815	.028	6	view →
GBM	DFS	Median	All	0.664	0.839	.012	6	view →
PDAC	DFS	Quartile	II,III,IV	0.394	0.704	.007	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DMAC2–UCEC (DFS)

Open the UCEC breakdown →