DMAC2

Across TCGA patient cohorts, DMAC2 mutation is significantly associated with the RNA expression of many other genes, with 1,828 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMAC2-associated genes across cancer lineages are MIR6894, IGHD5-18, and USP9YP34. Each is linked with DMAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMAC2-to-partner and partner-to-DMAC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6894 grouped by DMAC2-low versus DMAC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMAC2→partner) and Y-score (partner→DMAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6894 →	+0.474	+1.981	.005	.007	3	2
CESC	IGHD5-18 →	+1.307	+4.669	<.001	.007	3	2
BRCA	USP9YP34 →	+0.029	+8.471	<.001	.005	3	2
CESC	OR2AI1P →	+0.049	+4.669	<.001	.007	3	1
CESC	RPL34P17 →	+0.142	+4.539	<.001	.008	3	1
CESC	LINC01414 →	+0.258	+4.320	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

MIR6894 by DMAC2 expression — UCEC

Explore this box plot interactively →