DMAC1

Across TCGA pan-cancer cohorts, DMAC1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DMAC1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DMAC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DMAC1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where DMAC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.491	0.892	.019	7	view →
PDAC	OS	Median	II,III,IV	0.966	0.721	.003	7	view →
CCRCC	DFS	Median	II,III,IV	0.834	0.962	.024	5	view →
OV	DFS	Tertile	All	1.000	0.715	.040	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.868	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DMAC1–LUAD (DFS)

Open the LUAD breakdown →