DMAC1

Across TCGA patient cohorts, DMAC1 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DMAC1-associated genes across cancer lineages are RNU6-1248P, RNA5SP115, and ZNF385D-AS2. Each is linked with DMAC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DMAC1-to-partner and partner-to-DMAC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1248P grouped by DMAC1-low versus DMAC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DMAC1→partner) and Y-score (partner→DMAC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1248P →	+0.671	+5.497	<.001	.004	3	1
BLCA	RNA5SP115 →	+0.312	+5.788	<.001	.003	3	1
BLCA	ZNF385D-AS2 →	+0.084	+7.040	<.001	<.001	3	1
BLCA	LINC01831 →	+2.622	+5.497	<.001	.004	3	1
BLCA	RPL7P30 →	+0.052	+5.106	.009	.008	3	1
BLCA	H3P29 →	+0.119	+5.685	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

RNU6-1248P by DMAC1 expression — BLCA

Explore this box plot interactively →