DLX6

Across TCGA patient cohorts, DLX6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,812 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DLX6-associated genes across cancer lineages are PLCB4, DLX5, and PLEKHA8. Each is linked with DLX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX6-to-partner and partner-to-DLX6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DLX6 versus PLCB4 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX6→partner) and Y-score (partner→DLX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PLCB4 →	+1.035	+0.841	<.001	<.001	3	2
UCEC	DLX5 →	+2.206	+0.741	<.001	<.001	3	2
UCEC	PLEKHA8 →	+0.444	+0.509	<.001	.005	3	2
LSCC	FKTN →	+0.407	+0.581	<.001	.003	3	2
UCEC	RAB11FIP2 →	+1.017	+0.725	<.001	.001	3	2
UCEC	FGF8 →	+0.728	+0.543	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,812 associations by consensus.

DLX6 vs PLCB4 — LSCC

Explore this scatter interactively →