DLX6

Across TCGA patient cohorts, DLX6 mutation is significantly associated with the RNA expression of many other genes, with 128 significant associations in total. COAD shows the largest number of these associations.

The most reproducible DLX6-associated genes across cancer lineages are ZNRF4, OR12D3, and CSH1. Each is linked with DLX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX6-to-partner and partner-to-DLX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by DLX6-low versus DLX6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX6→partner) and Y-score (partner→DLX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNRF4 →	+1.046	+5.693	<.001	.003	3	2
SCLC	OR12D3 →	+0.041	+4.039	<.001	.009	3	2
SCLC	CSH1 →	+0.217	+4.774	<.001	<.001	3	2
SCLC	OR2T6 →	+0.162	+4.039	<.001	.009	3	2
SCLC	KRTAP6-3 →	+0.219	+4.039	<.001	.009	3	2
BRCA	IFNA4 →	+0.064	+4.386	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 128 associations by consensus.

ZNRF4 by DLX6 expression — COAD

Explore this box plot interactively →