DLX6

Across TCGA cell cohorts, DLX6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,320 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible DLX6-associated GO terms across cancer lineages are RNA splicing, via transesterification reactions, RNA splicing, via transesterification reactions with bulged adenosine as nucleophile, and mRNA splicing, via spliceosome. Each is linked with DLX6 in more than 10 cancer types. Because this analysis shows association rather than direction, both DLX6-to-partner and partner-to-DLX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via transesterification reactions grouped by DLX6-low versus DLX6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX6→partner) and Y-score (partner→DLX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.068	+1.164	<.001	.003	3	11
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.069	+1.186	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	mRNA splicing, via spliceosome →	+0.069	+1.186	<.001	.002	3	11
LIVER	Positive regulation of DNA repair →	+0.092	+2.366	<.001	<.001	3	10
LIVER	Protein-RNA complex organization →	+0.069	+1.898	.006	.009	3	9
LIVER	Regulation of DNA repair →	+0.058	+1.668	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,320 associations by consensus.

RNA splicing, via transesterification reactions by DLX6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →