DLX6

Across TCGA cell cohorts, DLX6 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLX6-associated genes across cancer lineages are CENPVL3, MTMR8, and SCGB1D2. Each is linked with DLX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX6-to-partner and partner-to-DLX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL3 grouped by DLX6-low versus DLX6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX6→partner) and Y-score (partner→DLX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPVL3 →	+0.179	+2.727	<.001	<.001	3	2
CNS	MTMR8 →	+0.720	+3.684	<.001	.003	3	1
CNS	SCGB1D2 →	+0.673	+3.657	<.001	.006	3	1
CNS	PZP →	+0.449	+3.157	<.001	.008	3	1
CNS	SLC22A7 →	+0.047	+3.409	<.001	.002	3	1
CNS	SLC28A1 →	+0.118	+3.358	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

CENPVL3 by DLX6 expression — LARGE_INTESTINE

Explore this box plot interactively →