DLX5

Across TCGA patient cohorts, DLX5 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX5-associated genes across cancer lineages are Notch1, STAT3_pY705, and Tuberin. Each is linked with DLX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX5-to-partner and partner-to-DLX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DLX5-low versus DLX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX5→partner) and Y-score (partner→DLX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.175	+3.009	.017	.019	3	2
UCEC	STAT3_pY705 →	-0.605	-3.321	<.001	.010	3	1
UCEC	Tuberin →	+0.403	+3.321	.004	.010	3	1
UCEC	VHL →	-0.790	-3.000	.026	.036	3	1
UCEC	Cyclin-B1 →	+0.765	+3.321	.009	.010	3	1
LUAD	FASN →	+0.583	+3.000	.017	.036	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Notch1 by DLX5 expression — UCEC

Explore this box plot interactively →