DLX5

Across TCGA cell cohorts, DLX5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DLX5-associated genes across cancer lineages are OR5AU1, KRTAP4-7, and ECE2. Each is linked with DLX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX5-to-partner and partner-to-DLX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AU1 grouped by DLX5-low versus DLX5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX5→partner) and Y-score (partner→DLX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR5AU1 →	+0.019	+4.734	.007	.002	3	1
LUNG_NSCLC_LUAD	KRTAP4-7 →	+0.206	+4.212	<.001	.007	3	1
LARGE_INTESTINE	ECE2 →	+0.360	+4.054	<.001	.004	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.130	+4.108	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR5AU1 by DLX5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →