DLX3

Across TCGA patient cohorts, DLX3 mutation is significantly associated with the RNA expression of many other genes, with 978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX3-associated genes across cancer lineages are MIR7-2, IGHD2-2, and CYCSP32. Each is linked with DLX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX3-to-partner and partner-to-DLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7-2 grouped by DLX3-low versus DLX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX3→partner) and Y-score (partner→DLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7-2 →	+0.263	+3.036	<.001	<.001	3	2
UCEC	IGHD2-2 →	+1.063	+2.235	.004	<.001	3	2
UCEC	CYCSP32 →	+0.108	+2.216	<.001	.007	3	2
CESC	TRAJ12 →	+0.680	+4.608	<.001	.001	3	2
STAD	TTTY8 →	+0.024	+5.012	<.001	.003	3	1
STAD	OR2U1P →	+0.155	+4.139	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 978 associations by consensus.

MIR7-2 by DLX3 expression — UCEC

Explore this box plot interactively →