DLX3

Across TCGA patient cohorts, DLX3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX3-associated genes across cancer lineages are EGFR_pY1068, GAPDH, and TSC1. Each is linked with DLX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX3-to-partner and partner-to-DLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DLX3-low versus DLX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX3→partner) and Y-score (partner→DLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.344	-3.000	<.001	.001	3	2
UCEC	GAPDH →	+0.574	+1.807	.009	.027	3	2
UCEC	TSC1 →	-0.233	-3.130	<.001	.018	3	2
UCEC	eEF2 →	+0.377	+1.807	.010	.027	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.321	.005	.034	3	1
UCEC	JNK2 →	+0.170	+2.179	.038	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by DLX3 expression — UCEC

Explore this box plot interactively →