DLX3

Across TCGA cell cohorts, DLX3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLX3-associated genes across cancer lineages are IL2, OR10A4, and OR11H6. Each is linked with DLX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX3-to-partner and partner-to-DLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by DLX3-low versus DLX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX3→partner) and Y-score (partner→DLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IL2 →	+0.034	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR10A4 →	+0.045	+2.938	.007	.007	3	1
CNS	OR11H6 →	+0.035	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IL2 by DLX3 expression — LARGE_INTESTINE

Explore this box plot interactively →