DLX2

Across TCGA patient cohorts, DLX2 mutation is significantly associated with the RNA expression of many other genes, with 833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX2-associated genes across cancer lineages are RN7SKP228, JAKMIP1, and ABHD3. Each is linked with DLX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX2-to-partner and partner-to-DLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP228 grouped by DLX2-low versus DLX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX2→partner) and Y-score (partner→DLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SKP228 →	+0.154	+4.970	<.001	.005	3	2
UCEC	JAKMIP1 →	+0.605	+3.584	.001	.002	3	2
UCEC	ABHD3 →	+0.836	+3.606	<.001	.001	3	2
UCEC	CTLA4 →	+0.714	+3.475	.005	.002	3	2
UCEC	CHAF1A →	+0.509	+2.343	.009	.003	3	2
UCEC	NIPA1 →	+0.806	+2.343	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 833 associations by consensus.

RN7SKP228 by DLX2 expression — SKCM

Explore this box plot interactively →