DLX2

Across TCGA patient cohorts, DLX2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLX2-associated genes across cancer lineages are PRDX1, Shc_pY317, and c-Jun_pS73. Each is linked with DLX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX2-to-partner and partner-to-DLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by DLX2-low versus DLX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX2→partner) and Y-score (partner→DLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.263	+2.999	.008	.035	3	2
UCEC	Shc_pY317 →	-0.172	-3.169	.019	.019	3	2
UCEC	c-Jun_pS73 →	-0.158	-2.459	.039	.020	3	2
UCEC	EGFR_pY1068 →	-0.351	-3.584	.003	.002	2	2
UCEC	eIF4E →	+0.243	+2.459	.016	.020	3	1
UCEC	IGFBP2 →	-0.784	-2.459	.012	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PRDX1 by DLX2 expression — UCEC

Explore this box plot interactively →