DLX1

Across TCGA cell cohorts, DLX1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLX1-associated genes across cancer lineages are SCYGR10, GUCY2F, and GSG1L2. Each is linked with DLX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLX1-to-partner and partner-to-DLX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCYGR10 grouped by DLX1-low versus DLX1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLX1→partner) and Y-score (partner→DLX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SCYGR10 →	+0.109	+5.781	<.001	.001	3	1
LARGE_INTESTINE	GUCY2F →	+0.010	+4.273	.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.020	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SCYGR10 by DLX1 expression — BREAST

Explore this box plot interactively →