DLST

Across TCGA pan-cancer cohorts, DLST mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DLST data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DLST mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DLST expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, LUAD, and HNSC are the cancer types where DLST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.911	0.807	.018	12	view →
LUAD	DFS	Quartile	All	0.451	0.858	.008	11	view →
HNSC	DFS	Median	III,IV	0.752	0.519	.015	5	view →
LSCC	OS	Tertile	II,III,IV	0.862	0.484	.008	4	view →
PDAC	DFS	Quartile	III,IV	0.418	0.832	.033	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DLST–GBM (OS)

Open the GBM breakdown →