DLST

Across TCGA cell cohorts, DLST RNA expression is significantly associated with the go_rna of many other GO terms, with 3,284 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DLST-associated GO terms across cancer lineages are DNA-templated DNA replication, Negative regulation of mRNA splicing, via spliceosome, and Replication fork processing. Each is linked with DLST in more than 12 cancer types. Because this analysis shows association rather than direction, both DLST-to-partner and partner-to-DLST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated DNA replication grouped by DLST-low versus DLST-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLST→partner) and Y-score (partner→DLST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.113	+0.805	<.001	.003	3	13
URINARY_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.101	+0.898	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Replication fork processing →	+0.113	+0.825	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication maintenance of fidelity →	+0.113	+0.812	<.001	.002	3	12
BLOOD_Lymphoma	Nuclear transport →	+0.069	+0.942	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	DNA replication →	+0.100	+0.780	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,284 associations by consensus.

DNA-templated DNA replication by DLST expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →