DLL4

Across TCGA pan-cancer cohorts, DLL4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DLL4 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DLL4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DLL4 expression acts as an unfavorable survival marker.

HNSC, UCEC, and BLCA are the cancer types where DLL4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.197	0.686	.012	27	view →
UCEC	OS	Median	IV	0.225	0.772	<.001	12	view →
BLCA	OS	Median	All	0.492	0.711	.045	6	view →
STAD	DFS	Median	III,IV	0.149	0.606	.004	3	view →
SKCM	OS	Median	II,III,IV	0.581	0.850	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DLL4–HNSC (OS)

Open the HNSC breakdown →