DLL3

Across TCGA patient cohorts, DLL3 protein abundance is significantly associated with the RNA expression of many other genes, with 3,487 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DLL3-associated genes across cancer lineages are SPECC1L, YPEL1, and SNRPD3. Each is linked with DLL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL3-to-partner and partner-to-DLL3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DLL3 versus SPECC1L in GBM, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL3→partner) and Y-score (partner→DLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPECC1L →	+0.316	+0.601	<.001	.003	3	1
GBM	YPEL1 →	+0.719	+0.810	<.001	<.001	3	1
GBM	SNRPD3 →	+0.382	+0.586	<.001	<.001	3	1
GBM	CYTH4 →	-0.999	-0.624	<.001	<.001	3	1
GBM	ESS2 →	+0.301	+0.606	<.001	<.001	3	1
GBM	HIRA →	+0.290	+0.572	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,487 associations by consensus.

DLL3 vs SPECC1L — GBM

Explore this scatter interactively →