DLL3

Across TCGA patient cohorts, DLL3 mutation is significantly associated with the RNA expression of many other genes, with 2,252 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLL3-associated genes across cancer lineages are GFM2, PBK, and ZWILCH. Each is linked with DLL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLL3-to-partner and partner-to-DLL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFM2 grouped by DLL3-low versus DLL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL3→partner) and Y-score (partner→DLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GFM2 →	+0.736	+2.609	<.001	.006	3	3
UCEC	PBK →	+1.015	+3.584	<.001	.002	3	3
UCEC	ZWILCH →	+0.548	+2.681	.003	.004	3	3
UCEC	WSB2 →	+0.619	+3.617	<.001	.001	3	3
COAD	TYMS →	+0.970	+3.459	<.001	.005	3	3
UCEC	MPP5 →	+0.557	+2.343	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,252 associations by consensus.

GFM2 by DLL3 expression — UCEC

Explore this box plot interactively →