DLL3

Across TCGA patient cohorts, DLL3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLL3-associated genes across cancer lineages are ACC1, Cyclin-B1, and Di-Ras3. Each is linked with DLL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLL3-to-partner and partner-to-DLL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by DLL3-low versus DLL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL3→partner) and Y-score (partner→DLL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.405	+2.000	.013	.032	3	2
UCEC	Cyclin-B1 →	+0.723	+2.321	.004	.034	3	2
UCEC	Di-Ras3 →	-0.206	-2.000	.002	.032	3	2
COAD	eEF2 →	+0.366	+3.178	.012	.010	1	3
UCEC	ATM →	-0.829	-2.000	<.001	.032	1	3
COAD	Caveolin-1 →	-0.742	-3.161	.034	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ACC1 by DLL3 expression — UCEC

Explore this box plot interactively →