Across TCGA patient cohorts, DLL1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLL1-associated genes across cancer lineages are Cyclin-E2, EGFR_pY1068, and eIF4E. Each is linked with DLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL1-to-partner and partner-to-DLL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL1→partner) and Y-score (partner→DLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.171	+2.828	.021	.035	3	2
UCEC	EGFR_pY1068 →	-0.171	-1.485	.019	.003	3	2
UCEC	eIF4E →	+0.193	+3.013	.001	<.001	3	2
UCEC	JNK2 →	+0.147	+1.115	.010	.026	3	2
UCEC	Notch1 →	+0.093	+1.293	.023	.031	3	2
UCEC	P-Cadherin →	-0.110	-2.415	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DLL1 survival (RNA) · tumor vs normal (RNA) · all DLL1 data types