Across TCGA cell cohorts, DLL1 mutation is significantly associated with the RNA expression of many other genes, with 1,011 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLL1-associated genes across cancer lineages are KRTAP4-4, OR2B3, and LILRB1. Each is linked with DLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLL1-to-partner and partner-to-DLL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLL1→partner) and Y-score (partner→DLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KRTAP4-4 →	+0.030	+4.807	<.001	.006	3	1
LUNG_SCLC	OR2B3 →	+0.023	+5.643	<.001	.002	3	1
OVARY	LILRB1 →	+0.187	+4.285	<.001	.001	3	1
OVARY	MS4A6E →	+0.048	+3.807	<.001	.009	3	1
LARGE_INTESTINE	SRRD →	+1.064	+3.169	<.001	.006	3	1
LARGE_INTESTINE	JOSD1 →	+0.581	+3.364	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,011 associations by consensus.

Exploration

DLL1 survival (RNA) · tumor vs normal (RNA) · all DLL1 data types