Across TCGA cell cohorts, DLK1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DLK1-associated genes across cancer lineages are CSN1S1, CSN2, and GUCA2A. Each is linked with DLK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLK1-to-partner and partner-to-DLK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLK1→partner) and Y-score (partner→DLK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CSN1S1 →	+0.830	+4.684	<.001	.002	3	1
SKIN	CSN2 →	+0.091	+4.415	<.001	.007	3	1
SKIN	GUCA2A →	+0.052	+4.273	.009	.006	3	1
SKIN	OR8J2 →	+0.052	+4.095	<.001	.009	3	1
LARGE_INTESTINE	TMCO5A →	+0.015	+3.678	<.001	.001	3	1
LARGE_INTESTINE	GPR171 →	+0.012	+2.688	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

DLK1 survival (RNA) · tumor vs normal (RNA) · all DLK1 data types