DLGAP5

Across TCGA patient cohorts, DLGAP5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLGAP5-associated genes across cancer lineages are Notch1, PCNA, and Annexin-1. Each is linked with DLGAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLGAP5-to-partner and partner-to-DLGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DLGAP5-low versus DLGAP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLGAP5→partner) and Y-score (partner→DLGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.172	+2.424	<.001	.001	3	2
UCEC	PCNA →	+0.239	+2.263	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.558	+1.926	.001	.008	3	2
UCEC	STAT3_pY705 →	-0.404	-1.938	<.001	.001	3	2
UCEC	Cyclin-B1 →	+0.899	+3.115	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.195	-2.643	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Notch1 by DLGAP5 expression — UCEC

Explore this box plot interactively →