DLGAP3

Across TCGA patient cohorts, DLGAP3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLGAP3-associated genes across cancer lineages are Smad1, Claudin-7, and eEF2. Each is linked with DLGAP3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLGAP3-to-partner and partner-to-DLGAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by DLGAP3-low versus DLGAP3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLGAP3→partner) and Y-score (partner→DLGAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Smad1 →	+0.296	+3.000	<.001	.033	3	2
STAD	Claudin-7 →	+1.214	+3.000	<.001	.036	3	2
UCEC	eEF2 →	+0.333	+1.584	.017	.036	3	2
UCEC	GAPDH →	+0.450	+2.999	.032	.035	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.516	-2.584	.003	.010	3	2
UCEC	VHL →	-1.093	-2.700	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Smad1 by DLGAP3 expression — STAD

Explore this box plot interactively →