Across TCGA pan-cancer cohorts, DLGAP1-AS4 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DLGAP1-AS4’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DLGAP1-AS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DLGAP1-AS4 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
HNSC, BLCA, and KIRC are the cancer types where DLGAP1-AS4 tumor–normal differential expression is most reproducible.