DLG3

Across TCGA patient cohorts, DLG3 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG3-associated genes across cancer lineages are CDK1, Caspase-7-cleavedD198, and FOXO3a. Each is linked with DLG3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DLG3-to-partner and partner-to-DLG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by DLG3-low versus DLG3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG3→partner) and Y-score (partner→DLG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.138	+1.125	<.001	.029	3	5
UCEC	Caspase-7-cleavedD198 →	+0.604	+2.321	<.001	<.001	3	3
UCEC	FOXO3a →	-0.066	-1.292	.015	.010	3	2
UCEC	Notch1 →	+0.120	+1.299	.001	.004	3	2
UCEC	p21 →	+0.107	+1.736	.038	.006	3	2
UCEC	TIGAR →	+0.094	+1.173	.022	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

CDK1 by DLG3 expression — UCEC

Explore this box plot interactively →