DLG3

Across TCGA cell cohorts, DLG3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLG3-associated genes across cancer lineages are TAS2R60, CHRNA4, and RAI2. Each is linked with DLG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLG3-to-partner and partner-to-DLG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAS2R60 grouped by DLG3-low versus DLG3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG3→partner) and Y-score (partner→DLG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TAS2R60 →	+0.021	+2.669	<.001	.004	3	1
BLOOD_Leukemia	CHRNA4 →	+0.020	+4.234	.001	.003	3	1
BLOOD_Leukemia	RAI2 →	+0.122	+4.428	<.001	.001	3	1
BLOOD_Leukemia	CRYGC →	+0.020	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IGFL1 →	+0.097	+3.769	<.001	.008	3	1
BLOOD_Leukemia	DIO3 →	+0.238	+3.934	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

TAS2R60 by DLG3 expression — LARGE_INTESTINE

Explore this box plot interactively →