DLG2

Across TCGA patient cohorts, DLG2 mutation is significantly associated with the total protein of many other genes, with 84 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLG2-associated genes across cancer lineages are eEF2, 4E-BP1, and Caspase-7-cleavedD198. Each is linked with DLG2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DLG2-to-partner and partner-to-DLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DLG2-low versus DLG2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG2→partner) and Y-score (partner→DLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.323	+3.321	.010	.009	3	4
LUAD	4E-BP1 →	+0.301	+2.321	.034	.035	3	4
COAD	Caspase-7-cleavedD198 →	+0.714	+1.753	.006	.047	3	4
UCEC	ATM →	-0.464	-1.700	<.001	<.001	3	3
COAD	Rictor_pT1135 →	-0.124	-2.115	.005	.015	3	3
UCEC	p38-MAPK →	-0.111	-1.202	.008	.032	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

eEF2 by DLG2 expression — STAD

Explore this box plot interactively →