DLG2

Across TCGA cell cohorts, DLG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,089 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DLG2-associated GO terms across cancer lineages are Protein localization to cytoplasmic stress granule, Regulation of metaphase plate congression, and Positive regulation of intracellular estrogen receptor signaling pathway. Each is linked with DLG2 in more than 9 cancer types. Because this analysis shows association rather than direction, both DLG2-to-partner and partner-to-DLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cytoplasmic stress granule grouped by DLG2-low versus DLG2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG2→partner) and Y-score (partner→DLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein localization to cytoplasmic stress granule →	+0.147	+0.406	.003	.006	3	9
LARGE_INTESTINE	Regulation of metaphase plate congression →	+0.095	+0.514	<.001	.002	3	9
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.153	+2.655	.009	.009	1	10
SOFT_TISSUE	Microtubule polymerization →	+0.105	+0.779	<.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of macrophage proliferation →	+0.194	+0.618	.001	.007	3	8
URINARY_TRACT	Base-excision repair, gap-filling →	+0.127	+0.459	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,089 associations by consensus.

Protein localization to cytoplasmic stress granule by DLG2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →