DLG2

Across TCGA cell cohorts, DLG2 mutation is significantly associated with the RNA expression of many other genes, with 449 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLG2-associated genes across cancer lineages are ACTR6, FETUB, and KLRG1. Each is linked with DLG2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DLG2-to-partner and partner-to-DLG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTR6 grouped by DLG2-low versus DLG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG2→partner) and Y-score (partner→DLG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACTR6 →	+0.677	+2.714	<.001	.002	3	3
LUNG_NSCLC_LUAD	FETUB →	+0.284	+3.574	<.001	.001	3	2
LUNG_NSCLC_LUAD	KLRG1 →	+0.815	+3.206	<.001	.006	3	2
LARGE_INTESTINE	INTS10 →	+0.643	+3.743	.001	<.001	3	2
LARGE_INTESTINE	NEIL3 →	+0.605	+3.067	.005	.009	3	2
LARGE_INTESTINE	ELP3 →	+0.545	+2.628	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 449 associations by consensus.

ACTR6 by DLG2 expression — LARGE_INTESTINE

Explore this box plot interactively →