DLG1

Across TCGA cell cohorts, DLG1 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLG1-associated genes across cancer lineages are KRTAP10-1, DPRX, and SYCN. Each is linked with DLG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLG1-to-partner and partner-to-DLG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP10-1 grouped by DLG1-low versus DLG1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLG1→partner) and Y-score (partner→DLG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	2
CNS	DPRX →	+0.068	+5.321	<.001	.005	3	2
BLOOD_Leukemia	SYCN →	+0.035	+4.539	<.001	.007	3	2
LUNG_NSCLC_LUSC	PRSS48 →	+0.063	+4.108	.004	.005	3	1
KIDNEY	APCS →	+0.033	+5.000	<.001	.005	3	1
KIDNEY	HMGB4 →	+0.306	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

KRTAP10-1 by DLG1 expression — SOFT_TISSUE

Explore this box plot interactively →