DLEU2L

Across TCGA pan-cancer cohorts, DLEU2L RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DLEU2L data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DLEU2L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DLEU2L expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

KICH, LGG, and READ are the cancer types where DLEU2L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.539	1.000	<.001	100	view →
LGG	DFS	Median	All	0.656	0.816	<.001	51	view →
READ	OS	Quartile	All	0.922	0.663	.001	45	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LIHC	DFS	Median	All	0.467	0.611	<.001	27	view →
HNSC	OS	Median	All	0.710	0.607	.006	23	view →
KIRC	DFS	Tertile	III,IV	0.560	0.753	.014	18	view →
BRCA	DFS	Tertile	III,IV	0.952	0.797	.003	18	view →
ESCA	OS	Tertile	IV	0.243	0.738	.024	12	view →
THCA	DFS	Tertile	IV	0.519	0.865	.019	10	view →
LUSC	DFS	Tertile	II,III,IV	0.301	0.535	.014	8	view →
SKCM	DFS	Tertile	IV	0.029	1.000	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DLEU2L–KICH (OS)

Open the KICH breakdown →