DLC1

Across TCGA patient cohorts, DLC1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,049 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DLC1-associated genes across cancer lineages are ITGA9, JAM2, and RCAN2. Each is linked with DLC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DLC1-to-partner and partner-to-DLC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DLC1 versus ITGA9 in LUAD, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLC1→partner) and Y-score (partner→DLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ITGA9 →	+0.754	+0.208	<.001	<.001	3	5
BRCA	JAM2 →	+1.005	+0.487	<.001	<.001	3	5
LUAD	RCAN2 →	+0.863	+0.218	<.001	.006	3	5
BRCA	CENPM →	-1.031	-0.488	<.001	<.001	3	4
LUAD	CHRDL1 →	+1.602	+0.268	<.001	<.001	3	4
BRCA	SRPX →	+1.010	+0.355	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,049 associations by consensus.

DLC1 vs ITGA9 — LUAD

Explore this scatter interactively →